Search results for "cell-culture media"
Article
A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
By Satish Mallya, Benjamin Lay, Lihong McAleer, Alexandria Emory, Nataliya Afonina
Abstract
Cell-culture media are essential raw materials that are required for the manufacture of biotherapeut…
Article
Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
The resulting push to eliminate animal-sourced materials drove the innovation of cell-culture media technology, which ultimately gave rise to the impressive chemically-defined, animal-component-free p…
Article
Optimizing Late-Stage and Commercial Cell-Culture Processes
Optimizing Late-Stage and Commercial Cell-Culture Processes
Late-stage and commercial biomanufacturing pose a challenge to cell-culture processing.
By Feliza Mirasol
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Article
Cell-Culture Advances Test Bioreactor Performance Models
The evolution of cell-culture technology is driving the need for improvements in modeling solutions.
By Cynthia A. Challener
Modeling and simulation are recognized to provide assistance i…
Article
Impact of Media Components on CQAs of Monoclonal Antibodies
The complexity of composition of cell-culture media offers many challenges towards optimization of the individual media components (2–3).
The formulation of optimal culture media for propagation of…
Article
Concentrating Feed—an Applicable Approach to Improve Antibody Production
In this study, the authors evaluated different approaches to prepare highly concentrated feed media for fed-batch Chinese hamster ovary cell culture. By raising the pH or by adding surfactants, the fe…
Article
Implementation of Raw Material Control Strategies in the Manufacture of Single-Use Bioprocessing Containers
Levels of TBPP, oxidized TBPP, and bDtBPP (see structures in Figure 2) were measured in antioxidant standards, resins, films, sterilized containers, and finally, in cell-culture media that had been in…
Article
Platform Approach Speeds Process Development
A modular cell-culture platform demonstrates accelerated process development.
By Harald Bradl, Jan Bechmann, Benedikt Greulich, Markus Michael Mueller, Patrick Schulz, Thomas Wucherpfennig
C…
Article
QbD and PAT in Upstream and Downstream Processing
To gain perspective on the implementation of quality by design (QbD) and process analytical technology (PAT) in biopharmaceutical processing, BioPharm International spoke with Clinton Weber, as…
Article
A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
The authors describe the ways in which manufacturers can mitigate the risks related to the integrity of recombinant transgenes expressed in CHO cells.
By Luhong He, Christopher Frye
Abstract
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